1-Methylnicotinamide ameliorates lipotoxicity-induced oxidative stress and cell death in kidney proximal tubular cells
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- 作者：Yuki Tanakaa ; Shinji Kumea ; skume@belle.shiga-med.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Hisazumi Arakia ; Jun Nakazawaa ; Masami Chin-Kanasakia ; Shin-ichi Arakia ; Fumiyuki Nakagawaa ; b ; Daisuke Koyac ; Masakazu Hanedad ; Hiroshi Maegawaa ; Takashi Uzua
- 关键词：BSA ; bovine serum albumin ; Enpp3 ; ectonucleotide pyrophosphatase/phosphodiesterase 3 ; ESRD ; end stage renal disease ; FFA ; free fatty acid ; 4-HNE ; 4-hydroxy-2-nonenal ; HO-1 ; heme oxigenase-1 ; MCP-1 ; monocyte chemoattractant protein-1 ; 1-MNA ; 1-methylnicotinamide ; MnSOD ; manganese superoxide dismutase ; NAD ; nicotinamide adenine dinucleotide ; NAMPT ; nicotinamide phosphoribosyltransferase ; NMN ; nicotinamide mononucleotide ; NMNAT1 ; nicotinamide nucleotide adenylyltransferase 1 ; NNMT ; nicotinamide n-m
- 刊名：Free Radical Biology and Medicine
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：89
- 期：Complete
- 页码：831-841
- 全文大小：2562 K
文摘
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Renal NNMT expression level is associated with lipotoxicity-induced renal injury.
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10">NNMT-derived 1-NMA production is renoprotective in lipotoxicity-induced renal injury.
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15">1-MNA inhibits lipotoxicity-mediated mitochondrial ROS production.
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1-MNA supplementation improves lipotoxicity-induced renal injury in mice.