EBI2 Expression and Function: Robust in Memory Lymphocytes and Increased by Natalizumab in Multiple Sclerosis

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• 作者：Auré ; lie S. Clottu¹ ; ² ; ³ ; Amandine Mathias¹ ; Andreas W. Sailer⁴ ; Myriam Schluep⁵ ; Jö ; rg D. Seebach³ ; Renaud Du Pasquier¹ ; ⁵ ; Caroline Pot¹ ; ² ; ⁵ ; ⁶ ; ^{caroline.pot-kreis@chuv.ch}
• 关键词：oxysterols ; G protein-coupled receptor Epstein-Barr virus-induced gene 2 (EBI2) ; lymphocyte trafficking ; multiple sclerosis ; natalizumab
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：3 January 2017
• 年：2017
• 卷：18
• 期：1
• 页码：213-224
• 全文大小：2213 K
• 卷排序：18

文摘

EBI2 expression is maximal on human CD4+ T cells and CD19+ B cells EBI2 is functional in human T and B cells Natalizumab alters EBI2 expression and function in memory CD4+ T cells