RIP3 antagonizes a TSC2-mediated pro-survival pathway in glioblastoma cell death

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• 作者：Gregory Fettweis^a ; Emmanuel Di Valentin^b ; Laurent L'homme^a ; Cé ; dric Lassence^a ; Franck Dequiedt^c ; Marianne Fillet^d ; Isabelle Coupienne^a ; Jacques Piette^a ; ^{jpiette@ulg.ac.be}
• 关键词：5-ALA ; 5-aminolevulinic acid ; MK2 ; MAP Kinase-Activated Protein kinase 2 ; p38 ; Mitogen-Activated Protein kinase p38 ; PDT ; Photodynamic Therapy ; RIP ; Receptor Interacting Protein ; TSC ; Tuberous Sclerosis ; YWHA ; Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein ; 14-3-3 proteins
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1864
• 期：1
• 页码：113-124
• 全文大小：2272 K
• 卷排序：1864

文摘

TSC2 protects glioblastoma from PDT-induced cell death. Specific TSC2 S1254 phosphorylation by MK2 mediates a pro-survival autophagy. Pro-death kinase RIP3 forms a complex with TSC2 and 14-3-3 proteins. RIP3 interferes with TSC2 pro-survival mechanisms.