Deep Brain Stimulation of the Ventral Pallidum Attenuates Epileptiform Activity and Seizing Behavior in Pilocarpine-Treated Rats
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- 作者：Wilson Yua ; Ian Wallinga ; Autumn B. Smitha ; Adolfo Ramirez-Zamorab ; Julie G. Pilitsisa ; c ; Damian S. Shina ; shind@mail.amc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Basal ganglia ; Seizures ; Epilepsy ; Brainstem seizures ; Electrical stimulation
- 刊名：Brain Stimulation
- 出版年：2016
- 出版时间：March-April 2016
- 年：2016
- 卷：9
- 期：2
- 页码：285-295
- 全文大小：2453 K
文摘
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Ventral pallidum deep brain stimulation at 50 Hz (VP-DBS) had potent efficacy against forebrain and brainstem behavioral seizures in pilocarpine-treated rats.
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VP-DBS attenuated epileptiform activity in hippocampal, but not primary somatosensory cortex.
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Electrical stimulation excited ventral pallidal neuron activity in vitro and reduced substantia nigra reticulata and superior colliculus activity in vivo.
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Acute or chronic VP-DBS did not alter gross motor function or arousal state.