Convergence of Reinforcing and Anhedonic Cocaine Effects in the Ventral Pallidum
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- 作者：Meaghan Creed1 ; Niels R. Ntamati1 ; Ramesh Chandra2 ; Mary Kay Lobo2 ; Christian Lü ; scher1 ; 3 ; 4 ; christian.luscher@unige.ch" class="auth_mail" title="E-mail the corresponding author
- 刊名：Neuron
- 出版年：2016
- 出版时间：5 October 2016
- 年：2016
- 卷：92
- 期：1
- 页码：214-226
- 全文大小：5169 K
文摘
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The ventral pallidum (VP) integrates inputs from D1- and D2-MSNs from the NAc
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Cocaine exposure potentiates output of D1-MSNs and depresses output of D2-MSNs to the VP
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Plasticity at D1-MSN-to-VP synapses is implicated in behavioral sensitization to cocaine
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Plasticity at D2-MSN-to-VP synapses contributes to cocaine-induced negative affect