Using human brain imaging studies as a guide toward animal models of schizophrenia
详细信息 查看全文
- 作者：S.S. Bolkan ; F. Carvalho Poyraz ; C. Kellendonk ; ck491@columbia.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：CNO ; Clozapine-N-Oxide ; D2R ; dopamine D2 receptor ; dlPFC ; dorsolateral PFC ; DTI ; diffusion tensor imaging ; fMRI ; functional MRI ; GPe ; globus pallidus externa ; GPi ; globus pallidus interna ; MD ; medidorsal thalamus ; MIA ; maternal immune activation ; MRI ; magnetic resonance imaging ; MSNs ; medium spiny neurons ; PCP ; phencyclidine hydrochloride ; PET ; positron emission tomography ; PV ; protein parvalbumin ; rsfMRI ; resting state fMRI ; SNr ; substantia nigra pars reticulata ; VTA ; ventral tegmental area
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：3 May 2016
- 年：2016
- 卷：321
- 期：Complete
- 页码：77-98
- 全文大小：662 K
文摘
- •
Biological findings in schizophrenia with emphasis on brain imaging studies.
- •
Functional alterations observed with brain imaging as an entry point for animal models.
- •
Modeling altered striatal dopamine, thalamo-prefrontal and hippocampal functions in mice.
- •
How mouse models inform schizophrenia patient research.