Variation in the promoter of the human hormone sensitive lipase gene shows gender specific effects on insulin and lipid levels: results from the Ely study

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• 作者：Talmud ; Philippa J. ; Palmen ; Jutta ; Luan ; Jian’ ; an ; Flavell ; Dave ; Byrne ; Christopher D. ; et. al.
• 关键词：Hormone sensitive lipase ; Insulin resistance ; Fasting insulin levels ; Genetic polymorphism
• 刊名：Biochimica et Biophysica Acta (BBA)/Molecular Basis of Disease
• 出版年：2001
• 出版时间：November 29, 2001
• 年：2001
• 卷：1537
• 期：3
• 页码：239-244
• 全文大小：182 K

文摘

We previously identified a hormone sensitive lipase (HSL) promoter variant, −60C>G, which in vitro exhibits 40 % reduced promoter activity. In this study we examined the effect of the −60C>G on glycemic and lipid measures in the population based Ely study of metabolic function and insulin resistance in 218 middle-aged men and 276 middle-aged women. Adipose tissue HSL is the rate-limiting step in triglyceride lipolysis, generating free fatty acids for energy utilization. HSL is also expressed in pancreatic β-cells where its activity therefore may affect insulin secretion. In the women, carriers of the HSL −60G allele had significantly lower fasting insulin levels (P