Proteasome subunit and opioid receptor gene expression down-regulation induced by paraquat and maneb in human neuroblastoma SH-SY5Y cells
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- 作者：Francesca Felicia Caputi1 ; Donatella Carretta1 ; Francesca Lattanzio ; Martina Palmisano ; Sanzio Candeletti ; Patrizia Romualdi ; patrizia.romualdi@unibo.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：PQ ; paraquat ; MB ; maneb ; α-syn ; α-synuclein ; TH ; tyrosine hydroxylase ; PD ; Parkinson's disease ; SN ; substantia nigra ; UPS ; ubiquitin&ndash ; proteasome 26 S system ; CP ; core particle ; RP ; regulatory particle ; Rpt ; regulatory particle triphosphateses ; Rpn ; regulatory particle non-ATPases ; MOP ; μ-opioid receptor ; DOP ; δ-opioid receptor
- 刊名：Environmental Toxicology and Pharmacology
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：40
- 期：3
- 页码：895-900
- 全文大小：1073 K
文摘
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SH-SY5Y cells were exposed to paraquat and maneb, alone or in combination.
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TH and α-synuclein protein levels increased after 48 h pesticides exposure.
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Pesticides induced Rpt3 and β1 proteasome subunit gene expression down-regulation.
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Paraquat caused MOP and DOP receptor down-regulation.
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The investigated molecular targets are simultaneously affected by pesticide exposure.