SH-SY5Y cells were exposed to paraquat and maneb, alone or in combination.
TH and α-synuclein protein levels increased after 48 h pesticides exposure.
Pesticides induced Rpt3 and β1 proteasome subunit gene expression down-regulation.
Paraquat caused MOP and DOP receptor down-regulation.
The investigated molecular targets are simultaneously affected by pesticide exposure.