Properties of modified carboxymethyl cellulose and its use as bioactive compound

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• 作者：Altaf H. Basta^a ; ^{altaf_basta2004@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Houssni El-Saied^a ; Mervat M. El-Deftar^b ; Ahmed A. El-Henawy^a ; Hussein H. El-Sheikh^c ; ^d ; Essam H. Abdel-Shakour^c ; ^d ; Mohamed S. Hasanin^a
• 关键词：Novel nano-cellulose derivatives ; Nanomedicine ; CMC ; Antimicrobial active cellulose derivative ; Anti-cancer active cellulose derivative
• 刊名：Carbohydrate Polymers
• 出版年：2016
• 出版时间：20 November 2016
• 年：2016
• 卷：153
• 期：Complete
• 页码：641-651
• 全文大小：2815 K

文摘

The present study deals with synthesizing novel cellulose derivative, from modifying the carboxymethyl cellulose with amino phenylpropanoic acid (CMC-APP). The synthesized CMC-APP was evaluated as biological and anti-cancer active compound. The molecular structures of this active compound were built using the HyperChem program 7.5, together with conventional analysis (nitrogen content, FT-IR, and non-isothermal TGA analysis). Optimizing the CMC/APPA ratio was carried out as preliminary assessment step, via undetected antimicrobial activity measurement. The TEM study showed that, the synthesized cellulose CMC-APP derivative in the nano-scale particle size (range from 12.5 to 89.3 nm). Among all the tested microorganisms and MCF-7 breast cancer cells, the synthesized nano-cellulose derivative is possible used as safety medicine for microbial infections and cancers. The minimal inhibitory concentration (MIC) for Gram-positive bacteria, and gram-negative bacteria are 48.82 μg/mL and 97 μg/mL, respectively. While, the unicellular fungi and filamentous fungi are 12.2 μg/mL and 97.65 μg/mL, respectively. The cytotoxic index (IC50) for MCF-7 breast cancers is 50 μg/mL. Moreover, the computational study of ADMET (absorption, distribution, metabolism, elimination and toxic) properties, of the molecules showed that, this investigated nano-compound is good oral bioavailability.