Gambogic acid counteracts mutant p53 stability by inducing autophagy

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• 作者：Giorgia Foggetti ; Laura Ottaggio ; Debora Russo¹ ; Paola Monti ; Paolo Degan ; Gilberto Fronza ; Paola Menichini ; ^{paola.menichini@hsanmartino.it}
• 关键词：Gambogic acid ; Autophagy ; Mutant p53 ; Apoptosis
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：1864
• 期：2
• 页码：382-392
• 全文大小：1539 K
• 卷排序：1864

文摘

Gambogic acid induced autophagy in cancer cells carrying mutant and wild type p53. Autophagy contributes to mutant p53 degradation in cancer cells. Autophagy inhibition stabilized mutant p53. Autophagy partially contributes to GA-induced cell death in a time and dose-dependent manner.