Human treated dentin matrices combined with Zn-doped, Mg-based bioceramic scaffolds and human dental pulp stem cells towards targeted dentin regeneration
详细信息 查看全文
- 作者：Athina Bakopouloua ; Eleni Papachristoua ; Maria Bousnakia ; Christina Hadjichristoua ; Eleana Kontonasakia ; Anna Theocharidoua ; Lambrini Papadopouloub ; Nikolaos Kantiranisb ; George Zachariadisc ; Gabriele Leyhausend ; Werner Geurtsend ; Petros Koidisa ; pkoidis@dent.auth.gr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Mg-based ; Zn-doped bioceramic scaffolds ; Human Treated Dentin Matrices-hTDMs ; Dental Pulp Stem Cells-DPSCs ; Dentin regeneration
- 刊名：Dental Materials
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：32
- 期：8
- 页码：e159-e175
- 全文大小：4742 K
文摘
- •
Bioceramic scaffold/hTDM constructs favored odontogenic differentiation and biomineralization.
- •
Scaffolds released Mg2+, Ca2+, Si4+ and Zn2+ ions and hTDMs growth factors (TGFβ-1, DMP-1 and BMP-2).
- •
Mineralized Ca-P tissue, partially transformed into bioapatite was generated in the constructs.
- •
Hr-DMP-1 and hr-BMP-2 further enhanced odontogenic differentiation phenomena.