Diffusion tensor imaging of the optic chiasm in patients with intra- or parasellar tumor using readout-segmented echo-planar

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• 作者：Hirofumi Yamada^a ; Akira Yamamoto^a ; ^{yakira@kuhp.kyoto-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Tomohisa Okada^a ; Mitsunori Kanagaki^a ; Yasutaka Fushimi^a ; David A. Porter^b ; Masahiro Tanji^c ; Masato Hojo^c ; Susumu Miyamoto^c ; Kaori Togashi^a
• 关键词：Diffusion tensor imaging ; Readout-segmented echo planar imaging ; Optic pathway ; Intrasellar tumor ; Parasellar tumor
• 刊名：Magnetic Resonance Imaging
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：34
• 期：5
• 页码：654-661
• 全文大小：1075 K

文摘

To evaluate the impact of surgery on the optic pathway of patients with intra- or parasellar mass lesions, as evidenced by readout-segmented DTI.

Materials and methods

Twenty-four patients with intra- or parasellar mass lesions were included in the study. Readout-segmented DTI and T2WI were obtained before and after surgery. The ROIs were set on the optic chiasm as well as the anterior and posterior optic tracts. For each ROI, axial diffusivity (AD), radial diffusivity (RD), fractional anisotropy (FA), and ADC values were calculated. DTI parameters in preoperative studies of all patients were compared and related to the presence of tumor compression. In patients who underwent surgery, pre- and postoperative DTI parameters were compared. The correlation between DTI parameters and visual function was determined.

Results

In the preoperative studies, the optic chiasm of patients with tumor compression showed significant lower AD and RD values. The optic chiasm of patients with visual field disorder showed significantly lower AD and RD values compared to patients without the disorder. There was a negative correlation with a trend toward significance between FA values and visual field disorder scores. The comparative analysis of patients in pre- and postoperative studies showed that the optic chiasm of patients with tumor compression presented a significant lower FA (0.41 versus 0.30, p = 0.0068) and higher RD values after surgery.

Conclusions

DTI is a useful tool to assess the impact of surgery on the optic chiasm and nerve.