文摘
Patterns of delayed parity induced changes to the breast tissue which are both dependent and independent of exercise training completed between menarche and first pregnancy. While exercise training was beneficial for tumor latency and size, it did not mitigate enhanced collagen levels found in mammary tissue of delayed parity animals. Similarly, exercise training did not mitigate enhanced expression levels of several genes associated with breast cancer. However, there were exercise-dependent changes in the mammary gland. Exercise training prevented the development of inflammation and ductal hyperplasia. Exercise training also led to improved directional regulation of gene expression levels for Cdkn1c and Plau. Differential gene expression levels of mammary tissue Cdkn1c and Plau in animals physically active between menarche and first pregnancy suggest that these genes may play a role in exercise-induced protection against breast cancer later in life.