The apolipoprotein(a) size, pentanucleotide repeat, C/T(+93) polymorphisms of apolipoprotein(a) gene, serum lipoprotein(a) concentrations and their relationship in a Korean population

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• 作者：Kim ; Jeong-Ho ; Roh ; Kyung Ho ; Nam ; Sang Min ; Park ; Hyun-Young ; Jang ; Yangsoo ; Kim ; Dong Kee ; et. al.
• 关键词：Apolipoprotein(a) ; Lipoprotein(a) ; C/T polymorphism ; Kringle 4 variable number of tandem repeat ; Pentanucleotide repeat polymorphism
• 刊名：Clinica Chimica Acta
• 出版年：2001
• 出版时间：December, 2001
• 年：2001
• 卷：314
• 期：1-2
• 页码：113-123
• 全文大小：235 K

文摘

Background: In addition to apolipoprotein(a) [apo(a)] kringle 4 variable number of tandem repeat (K4-VNTR), pentanucleotide repeat polymorphism (PNRP) and C/T(+93) polymorphism [C/T(+93)] of apo(a) gene have been suggested to be related to lipoprotein(a) [Lp(a)] concentration. We studied the distribution of these genetic polymorphisms and their relationship with Lp(a) concentrations in a Korean population. Methods: One hundred thirty-two Korean adults were examined. Lp(a) was measured with enzyme-linked immunosorbent assay (ELISA). Apo(a) K4-VNTR was measured by high-resolution SDS-agarose gel separation and ECL Western blotting method. PNRP was measured after DNA amplification. The C/T(+93) ratio was measured by a amplification refractory mutation system. Results: Lp(a) was inversely correlated with K4-VNTR (r