Water-soluble and organic extracts of airborne particulate matter induce micronuclei in human lung epithelial A549 cells

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• 作者：Isabel C. Palacio^a ; ^b ; ^icpb@usp.br ; Silvia B.M. Barros^b ; ^{smbarros@usp.br} ; Deborah A. Roubicek^a ; ^{droubicek@sp.gov.br}
• 关键词：Airborne particulate matter (PM10) ; Water-soluble extract ; Organic extract ; Micronuclei ; A549 cells
• 刊名：Mutation Research/Genetic Toxicology and Environmental Mutagenesis
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：812
• 期：Complete
• 页码：1-11
• 全文大小：1690 K
• 卷排序：812

文摘

Mutagenicity of water-soluble and organic extracts of PM10 was analyzed. Both extracts induce micronuclei in human alveolar carcinoma cells A549 cells. The PAHs prevailing in the samples were fluoranthene and benzo(ghi)perylene. The highest concentration of metals were found for zinc, iron, and copper. Genetic biomarkers for both fractions can useful in air-quality monitoring programs.