In vitro effects of metals on isolated head-kidney and blood leucocytes of the teleost fish Sparus aurata L. and Dicentrarchus labrax L.
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- 作者：Patricia Morcillo ; José ; Meseguer ; M. Á ; ngeles Esteban ; Alberto Cuesta ; alcuesta@um.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：Leucocytes ; Metals ; Teleost fish ; Immunity ; Oxidative stress ; Cell death
- 刊名：Fish & Shellfish Immunology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：54
- 期：Complete
- 页码：77-85
- 全文大小：702 K
文摘
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In vitro cytotoxicity of metals to seabream and sea bass leucocytes follows the order of MeHg > Cd > As > Pb.
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Sea bass leucocytes are more resistant to metals than seabream leucocytes. PBLs also more resistant than HKLs.
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Leucocytes show alteration of oxidative stress and cellular protection leading to apoptosis.
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Metals down-regulated the expression of immune-relevant genes in vitro.