IMPDH2 Is an Intracellular Target of the Cyclophilin A and Sanglifehrin A Complex

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• 作者：Khian Hong Pua¹ ; ² ; Dylan T. Stiles¹ ; ² ; Mathew E. Sowa² ; ³ ; Gregory L. Verdine¹ ; ² ; ⁴ ; ⁵ ; ^{gregory_verdine@harvard.edu}
• 关键词：cyclophilin A ; sanglifehrin A ; inosine-5&prime ; -monophosphate dehydrogenase ; cystathionine-β-synthase domains ; protein-protein interactions
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：18
• 期：2
• 页码：432-442
• 全文大小：2703 K
• 卷排序：18

文摘

SFA engages IMPDH2 in a PPIA-dependent manner PPIA-SFA interaction with IMPDH is highly isoform specific PPIA-SFA complex binds the CBS domains of IMPDH2 CBS domains of IMPDH2 are implicated in cellular proliferation