Highly sensitive method for simultaneous determination of nine alkaloids of Shuanghua Baihe tablets in human plasma by LC-MS/MS and its application
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- 作者：Yao Wua ; b ; 1 ; Ruijuan Liua ; b ; 1 ; Pan Gua ; b ; Minlu Chenga ; b ; Lu Zhengc ; Yujie Liuc ; Pengcheng Mad ; Li Dinga ; b ; dinglidl@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：SBT ; Shuanghua Baihe tablets ; RAS ; recurrent aphthous stomatitis ; TCM ; traditional Chinese medicine ; TCMs ; traditional Chinese medicines ; LLOQ ; lower limit of quantification ; IS ; internal standard ; MRM ; multiple reaction monitoring ; PPT ; protein precipitation ; LLE ; liquid&ndash ; liquid extraction
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2015
- 出版时间：15 December 2015
- 年：2015
- 卷：1007
- 期：Complete
- 页码：81-92
- 全文大小：2011 K
文摘
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A novel LC–MS/MS method for simultaneous determination of nine alkaloids in human plasma.
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Highly sensitive, the LLOQs of 1.5 pg/ml for palmatine and jatrorrhizine, and 15 pg/ml for the others.
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The gradient elution was adopted to overcome the matrix effect.
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Pharmacokinetics of the nine alkaloids of Shuanghua Baihe tablets in human were reported firstly.