Exploiting the Achilles’ heel of membrane trafficking in trypanosomes

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• 作者：Martin Zoltner¹ ; David Horn¹ ; Harry P de Koning² ; Mark C Field¹ ; ^{mfield@mac.com}
• 刊名：Current Opinion in Microbiology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：34
• 期：Complete
• 页码：97-103
• 全文大小：508 K
• 卷排序：34

文摘

Development of new drugs against trypanosomes is a crucial but unmet need. Membrane transport, endocytosis and related processes have been proposed as drug targets. Recent insights uncovered the mode of action of two drugs that are already in the clinic. Both of these drugs, suramin and pentamidine, bind surface proteins. It is possible that endocytosis is a common component of sensitivity to suramin and pentamidine.