Three pentraxins C-reactive protein, serum amyloid p component and pentraxin 3 mediate complement activation using Collectin CL-P1

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• 作者：Nitai Roy^a ; ¹ ; Katsuki Ohtani^a ; ¹ ; Yoshihiko Hidaka^b ; Yoshiro Amano^c ; Yasuyuki Matsuda^a ; Kenichiro Mori^a ; Insu Hwang^a ; Norimitsu Inoue^d ; Nobutaka Wakamiya^a ; ^{wakamiya@asahikawa-med.ac.jp}
• 关键词：Pentraxins ; PTXs ; CRP ; C-reactive protein ; PTX3 ; pentraxin 3 ; SAP ; serum amyloid P component ; NPTX1 ; neuronal pentraxin 1 ; NPTX2 ; neuronal pentraxin 2 ; NPTXR ; neuronal pentraxin receptor ; APR ; acute phase reaction ; CL-P1 ; collectin placenta 1 ; CRD ; carbohydrate recognition domain ; TCC ; terminal complement complex ; SR ; scavenger receptor ; CHO ; Chinese hamster ovary ; HEK ; human embryonic kidney ; DMEM ; Dulbecco's minimal essential medium ; FBS ; fetal bovine serum ; PBS ; phosphate-buffered saline ; TBS
• 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：1861
• 期：2
• 页码：1-14
• 全文大小：3302 K
• 卷排序：1861

文摘

The interaction of CRP, SAP, and PTX3 with collectin CL-P1 activates complement mainly through the classical pathway. Initiation of the classical pathway provokes the alternative pathway and the properdin dependent amplification pathway. CRP and PTX3 recruit CFH while SAP recruits C4BP on CL-P1 surfaces to prevent TCC formation. CFH, C4BP and CFI depleted serum failed to prevent TCC formation on CL-P1.