Effect of molecular weight on the transepithelial transport and peptidase degradation of casein-derived peptides by using Caco-2 cell model
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- 作者：Bo Wanga ; Bo Lia ; b ; libo@cau.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Casein peptide ; Molecular weight (MW) ; Transepithelial transport ; Brush-border peptidase (BBP) ; Hydrolysis ; Bioavailability
- 刊名：Food Chemistry
- 出版年：2017
- 出版时间：1 March 2017
- 年：2017
- 卷：218
- 期：Complete
- 页码：1-8
- 全文大小：1352 K
文摘
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We studied the effects of molecular weight on the transport routes of peptides.
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The brush-border peptidases are the limiting enzymes for peptide bioavailability.
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Peptides transported by PepT1 have higher bioavailability than peptides transported by paracellular route.
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Amino acid sequence of short chain peptides affects their bioavailability.