Changes in hunger and fullness in relation to gut peptides before and after 8 weeks of alternate day fasting

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• 作者：Kristin K. Hoddy^a ; Catherine Gibbons^b ; Cynthia M. Kroeger^a ; John F. Trepanowski^a ; Adrienne Barnosky^a ; Surabhi Bhutani^a ; Kelsey Gabel^a ; Graham Finlayson^b ; Krista A. Varady^a ; ^{varady@uic.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Alternate day fasting ; Calorie restriction ; Hunger ; Fullness ; Gut peptides ; Obese adults
• 刊名：Clinical Nutrition
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：35
• 期：6
• 页码：1380-1385
• 全文大小：522 K

文摘

Alternate day fasting (ADF; 25% energy intake “fast day”, alternated with an ad libitum intake “feed day”) is effective for weight loss. Whether or not ADF modulates hunger, fullness and gut peptides in a way that enhances dietary compliance and weight loss, remains unknown. Accordingly, this study examined the effect of ADF on postprandial appetite ratings and gut peptides.

Methods

Obese subjects (n = 59) participated in an 8-week ADF protocol where food was provided on the fast day.

Results

Body weight decreased (P < 0.0001) by 3.9 ± 0.6 kg after 8 weeks of diet. Reductions (P < 0.05) in fat mass (−2.2 ± 0.2 kg), fat free mass (−1.4 ± 0.2 kg), visceral fat mass (−0.1 ± 0.1 kg), and resting metabolic rate (RMR; −104 ± 28 kcal/day) were also observed. Fasting leptin and insulin decreased (P < 0.05), while AUC ghrelin levels increased (P < 0.05). Despite these metabolic changes, there was no increase in subjective hunger by the end of the study. Furthermore, fullness and PYY increased (P < 0.05). Fat free mass and RMR were not related to hunger or ghrelin at any time point.

Conclusion

These findings suggest that the absence of a compensatory increase in hunger in conjunction with an increase in sensations of fullness may contribute to the weight loss efficacy of an 8-week ADF regimen.