Effects of perfluorinated alkyl acids on cellular responses of MCF-10A mammary epithelial cells in monolayers and on acini formation in vitro
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- 作者：Ruth Halsnea ; ruth.halsne@nmbu.no" class="auth_mail" title="E-mail the corresponding author ; Julia Isabel Tandbergb ; Viola Hé ; lè ; ne Lobertc ; Gunn Charlotte Ø ; stbya ; Even Thoena ; d ; Erik Ropstada ; Steven Verhaegena
- 关键词：Persistent organic pollutants ; Epithelial polarisation ; β-Catenin ; GM130 ; Perfluorooctane sulfonate ; Perfluorooctanoic acid ; Perfluorononanoic acid ; Perfluorodecanoic acid ; Perfluoroundecanoic acid
- 刊名：Toxicology Letters
- 出版年：2016
- 出版时间：30 September 2016
- 年：2016
- 卷：259
- 期：Complete
- 页码：95-107
- 全文大小：2309 K
文摘
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PFOS, PFNA, and PFDA interfere with normal mammary epithelial morphogenesis in vitro.
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PFOA and PFUnDA have only weak or no effects in the MCF-10A acini model.
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The MCF-10A model can be used to explore estrogen receptor-independent mechanisms of environmental contaminants.