Selective serotonin reuptake inhibitors for depression in pregnancy

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• 作者：Leah C. Susser ; MD^a ; ^{lcs7001@med.cornell.edu} ; Stephanie A. Sansone ; MD^b ; Alison D. Hermann ; MD^a
• 关键词：antenatal depression ; antenatal exposure to antidepressant ; antenatal exposure to selective serotonin reuptake inhibitor ; antidepressant ; collaborative care ; depression in pregnancy ; in utero exposure to antidepressant ; in utero exposure to selective serotonin reuptake inhibitor ; perinatal depression ; selective serotonin reuptake inhibitor
• 刊名：American Journal of Obstetrics and Gynecology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：215
• 期：6
• 页码：722-730
• 全文大小：1825 K
• 卷排序：215

文摘

Perinatal depression is associated with a high risk of morbidity and mortality and may have long-term consequences on child development. The US Preventive Services Task Force has recently recognized the importance of identifying and treating women with depression in the perinatal period. However, screening and accessing appropriate treatment come with logistical challenges. In many areas, there may not be sufficient access to psychiatric care, and, until these resources develop, the burden may inadvertently fall on obstetricians. As a result, understanding the risks of perinatal depression in comparison with the risks of treatment is important. Many studies of selective serotonin reuptake inhibitors in pregnancy fail to control for underlying depressive illness, which can lead to misinterpretation of selective serotonin reuptake inhibitor risk by clinicians. This review discusses the risks and benefits of selective serotonin reuptake inhibitor treatment in pregnancy within the context of perinatal depression. Whereas selective serotonin reuptake inhibitors may be associated with certain risks, the absolute risks are low and may be outweighed by the risks of untreated depression for many women and their offspring.