Airway Memory CD4+ T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses
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- 作者：Jincun Zhao1 ; 2 ; 6 ; zhaojincun@gird.cn" class="auth_mail" title="E-mail the corresponding author ; Jingxian Zhao2 ; 6 ; Ashutosh K. Mangalam3 ; Rudragouda Channappanavar2 ; Craig Fett2 ; David K. Meyerholz3 ; Sudhakar Agnihothram4 ; 7 ; Ralph S. Baric4 ; Chella S. David5 ; Stanley Perlman2 ; stanley-perlman@uiowa.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Immunity
- 出版年：2016
- 出版时间：21 June 2016
- 年：2016
- 卷：44
- 期：6
- 页码：1379-1391
- 全文大小：4854 K
文摘
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Intranasal but not subcutaneous vaccination protects mice from pathogenic human CoVs
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Protection is mediated by airway memory CD4+ T cells
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IFN-γ produced by airway memory CD4+ T cells is required for protection
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A conserved epitope in SARS-CoV and MERS-CoV induces cross-reactive T cell responses