A fluorescent carbon-dots-based mitochondria-targetable nanoprobe for peroxynitrite sensing in living cells

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• 作者：Xiaoxue Wu^a ; ^b ; Shan Sun^b ; Yuhui Wang^b ; ^{wangyuhui@nimte.ac.cn} ; Jiali Zhu^b ; Kai Jiang^b ; Yumin Leng^b ; Qinghai Shu^a ; ^{qhshu121@bit.edu.cn} ; Hengwei Lin^b ; ^{linhengwei@nimte.ac.cn}
• 关键词：Carbon-dots ; Mitochondria-targeting ; Fluorescence imaging ; Nanoprobe ; Peroxynitrite
• 刊名：Biosensors and Bioelectronics
• 出版年：2017
• 出版时间：15 April 2017
• 年：2017
• 卷：90
• 期：Complete
• 页码：501-507
• 全文大小：705 K
• 卷排序：90

文摘

A fluorescent carbon-dots-based nanoprobe for peroxynitrite sensingin mitochondria is developed. The nanoprobe shows high sensitivity and selectivity towards peroxynitrite. The nanoprobe exhibits excellent biocompatibility and can be applied for peroxynitrite sensing in mitochondria. The carbon-dots can serve as promising nanocarriers for fabricating other organelle-targetable nanoprobes.