Moral Duties of Genomics Researchers: Why Personalized Medicine Requires a Collective Approach

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• 作者：Shoko Vos¹ ; ^{S.Vos-4@umcutrecht.nl} ; Johannes J.M. van Delden² ; Paul J. van Diest¹ ; Annelien L. Bredenoord²
• 关键词：genomics ; next-generation sequencing ; ethics ; moral duties ; cancer ; personalized medicine.
• 刊名：Trends in Genetics
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：33
• 期：2
• 页码：118-128
• 全文大小：1469 K
• 卷排序：33

文摘

Advances in genome sequencing together with the introduction of personalized medicine offer promising new avenues for research and precision treatment, particularly in the field of oncology. At the same time, the convergence of genomics, bioinformatics, and the collection of human tissues and patient data creates novel moral duties for researchers. After all, unprecedented amounts of potentially sensitive information are being generated. Over time, traditional research ethics principles aimed at protecting individual participants have become supplemented with social obligations related to the interests of society and the research enterprise at large, illustrating that genomic medicine is also a social endeavor. In this review we provide a comprehensive assembly of moral duties that have been attributed to genomics researchers and offer suggestions for responsible advancement of personalized genomic cancer care.