Flow cytometric detection of altered signaling in myelodysplastic syndrome and cytopenia
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- 作者：Juehua Gao ; j-gao@northwestern.edu" class="auth_mail" title="E-mail the corresponding author ; Suchitra Swaminathan ; Navin Pai ; Zachary Johnson ; Yi-Hua Chen ; LoAnn Peterson ; Charles Goolsby
- 关键词：Flow cytometry ; Myelodysplatic syndrome ; Phosphoprotein ; Growth factor
- 刊名：Leukemia Research
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：39
- 期：12
- 页码：1396-1404
- 全文大小：1764 K
文摘
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We evaluated the intracellular phosphoprotein in response to growth factors or cytokines.
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There was no characteristic signaling abnormality diagnostic for MDS.
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MDS cases were often associated with more signaling aberrancies in more cellular populations.
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Higher CD34+CD117 response to FL and SCF was frequently associated with high risk features in MDS.