Regional lung blood flow and ventilation in upright humans studied with quantitative SPECT

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• 作者：Johan Petersson ; Malin Rohdin ; Alej ; ro Sá ; nchez-Crespo ; Sven Nyré ; n ; Hans Jacobsson ; Stig A. Larsson ; Sten G.E. Lindahl ; Dag Linnarsson ; Blazej Neradilek ; Nayak L. Polissar ; Robb W. Glenny ; Ma
• 关键词：SPECT ; Lung blood flow ; Ventilation ; Regional perfusion ; Single-photon-emission computed tomography
• 刊名：Respiratory Physiology & Neurobiology
• 出版年：2009
• 出版时间：31 March 2009
• 年：2009
• 卷：166
• 期：1
• 页码：54-60
• 全文大小：431 K

文摘

We used quantitative Single Photon Emission Computed Tomography (SPECT) to study the effect of the upright posture on regional lung blood flow and ventilation. Nine (upright) plus seven (prone and supine) healthy volunteers were studied awake, breathing spontaneously. Regional blood flow and ventilation were marked in sitting upright, supine and prone postures using ^113mIn-labeled macroaggregates and inhaled Technegas (^99mTc); both remain fixed in the lung after administration. All images were obtained while supine. In comparison with horizontal postures, both blood flow and ventilation were greater in caudal regions when upright. The redistribution was greater for blood flow than for ventilation, resulting in decreasing ventilation-to-perfusion ratios down the lung when upright. We conclude that gravity redistributes regional blood flow and ventilation in the upright posture, while the influence is much less in the supine and prone postures.