MiR-21 inhibits autophagy by targeting Rab11a in renal ischemia/reperfusion
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- 作者：Xiujuan Liua ; xiujuan_liu796@163.com" class="auth_mail" title="E-mail the corresponding author ; Quan Hongb ; Zhen Wanga ; Yanyan Yua ; Xin Zoua ; Lihong Xua
- 关键词：I/R ; ischemia&ndash ; reperfusion ; AKI ; acute kidney injury ; AP ; autophagosome ; PAS ; phagophore assembly site ; COPD ; chronic obstructive pulmonary disease
- 刊名：Experimental Cell Research
- 出版年：2015
- 出版时间：15 October 2015
- 年：2015
- 卷：338
- 期：1
- 页码：64-69
- 全文大小：4066 K
文摘
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miR-21 inhibited autophagy during H/R in vitro.
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Rab11a was the direct target of miR-21.
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Rab11a mediated the effect of miR-21 during H/R injury.
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miR-21 inhibitors attenuated renal I/R injury in the rat model.
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miR-21 inhibitors enhanced autophagy in the renal I/R rat model.