Autophagosome Formation: Tracing the Source

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• 作者：Amé ; lie Bernard¹ ; Daniel J. Klionsky¹ ; ^{klionsky@umich.edu}
• 刊名：Developmental Cell
• 出版年：2013
• 出版时间：29 April, 2013
• 年：2013
• 卷：25
• 期：2
• 页码：116-117
• 全文大小：57 K

文摘

Although it is well appreciated that autophagy begins with phagophore formation and expansion through lipid acquisition to become the autophagosome, this process remains poorly understood, with the source of autophagosome membrane controversial. Reporting recently in Nature, suggest that the ER-mitochondria contact sites are involved in phagophore assembly.