Hepatitis delta in HIV/HBV co-infected patients in Brazil: is it important?

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• 作者：Maria Cá ; ssia Mendes-Correa^a ;   ; ^b ; Michele S. Gomes-Gouvê ; a^c ;   ; ^{gomesmic@yahoo.com.br} ; Mó ; nica V. Alvarado-Mora^c ; Mariliza H. Da Silva^d ; Carolina Lá ; zari^b ; Norma C.S. Cavalcanti^b ; Flaviane K. Alonso^a ; Cá ; tia C. Carpinelli^a ; David E. Uip^a ; Joã ; o R.R. Pinho^c
• 关键词：HIV ; Hepatitis B virus ; Hepatitis delta virus ; Co-infection ; Prevalence
• 刊名：International Journal of Infectious Diseases
• 出版年：2011
• 出版时间：December 2011
• 年：2011
• 卷：15
• 期：12
• 页码：e828-e832
• 全文大小：460 K

文摘

Summary

Objectives

This study was carried out to evaluate the prevalence of hepatitis delta virus (HDV) among human immunodeficiency virus (HIV)/hepatitis B virus (HBV) co-infected patients from S?o Paulo, in the Southeast Region of Brazil.

Methods

A total of 3259 HIV patients with serological markers for HBV were initially enrolled in the study. Among these patients, 154 (4.7 % ) were hepatitis B surface antigen (HBsAg)-reactive. Serum samples were obtained from 86 HBsAg-positive patients and were submitted to anti-HDV serological assay.

Results

One (1.2 % ) HIV/HBV patient was found to be anti-HDV-positive, and the HDV infection was confirmed by PCR. Phylogenetic analysis showed that this HDV sequence grouped with other HDV genotype 1 sequences from Mediterranean European countries, suggesting that this virus has a common ancestor with HDV from that region. This patient was probably infected by sexual transmission, as he reported unprotected sexual intercourse with multiple partners over the course of many years but denied intravenous drug use or any travel to the Brazilian Amazon, an area known to have a high HDV prevalence.

Conclusions

HDV infection is infrequent in the Southeast Region of Brazil, however there have been a few cases in this region. HIV/HBV patients are at potential risk for HDV infection, therefore investigations for the presence of HDV infection must be carried out in these patients.