Concise synthesis of tylophorine

详细信息    查看全文

• 作者：Qi-Xian Lin ; Tse-Lok Ho ; ^{tselokho@yahoo.com}
• 关键词：Phenanthroindolizidine alkaloid ; Tylophorine ; Stevens rearrangement ; Double Suzuki coupling ; Symmetry for synthesis design
• 刊名：Tetrahedron
• 出版年：2013
• 出版时间：8 April, 2013
• 年：2013
• 卷：69
• 期：14
• 页码：2996-3001
• 全文大小：574 K

文摘

The phenanthroindolizidine alkaloid tylophorine has been synthesized in the (R)- and racemic forms. One of the routes involves three steps from a known compound employing a Stevens rearrangement as the pivotal reaction. The phenanthrene moiety was constructed by either a base-catalyzed cyclization of 2-alkynylbiphenyls or a double Suzuki coupling of a 2,2¡ä-dibromobiphenyl with vic-bis(pinacolatoboryl)alkene in other routes.