Celecoxib treatment of fibrous dysplasia (FD) in a human FD cell line and FD-like lesions in mice with protein kinase A (PKA) defects

详细信息    查看全文

• 作者：Emmanouil Saloustros^a ; Sisi Liu^a ; Edward L. Mertz^b ; Nisan Bhattacharyya^c ; Matthew F. Starost^d ; Paraskevi Salpea^a ; Maria Nesterova^a ; Michael Collins^c ; Sergey Leikin^b ; Constantine A. Stratakis^a ; ^{stratakc@mail.nih.gov}
• 关键词：Cyclic AMP ; Prostaglandin E2 ; Cyclooxygenase-2 (COX-2) ; Bone tumors ; McCune-Albright syndrome ; Carney complex
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：439
• 期：Complete
• 页码：165-174
• 全文大小：3442 K
• 卷排序：439

文摘

Effect of systemic Celecoxib therapy in both human FD cells and mouse FDLL caused by Prkar1a deficiency. In vitro and in vivo Celecoxib treatment led to decreased proliferation of FD cells and FDLLs. Celecoxib treatment in mice improved the histologic phenotype and cortical bone organization of FDLLs associated with Prkar1a deficiency. This study presents promising results for the treatment of mice with bone lesions caused by Prkar1a deficiency. Potential role of Celecoxib in the treatment of patients with FD or CNC; however, to date no such human trail has been conducted.