Simultaneous determination of phenoxyethanol and its major metabolite, phenoxyacetic acid, in rat biological matrices by LC-MS/MS with polarity switching: Application to ADME studies
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- 作者：Tae Hwan Kima ; Min Gi Kima ; Min Gyu Kima ; Beom Soo Shinb ; Kyu-Bong Kimc ; Jong Bong Leea ; Soo Heui Paika ; Sun Dong Yooa ; sdyoo@skku.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Phenoxyethanol ; Phenoxyacetic acid ; LC&ndash ; MS/MS ; Percutaneous absorption ; Distribution ; Elimination
- 刊名：Talanta
- 出版年：2015
- 出版时间：1 November 2015
- 年：2015
- 卷：144
- 期：Complete
- 页码：29-38
- 全文大小：2154 K
文摘
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A simple LC–MS/MS method was developed for phenoxyethanol and phenoxyacetic aicd.
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Polarity switching was used for simultaneous determination.
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The assay was fully validated for rat plasma, urine and 7 different tissues.
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The method was applied to topical absorption and disposition studies in rats.
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Tissue distribution of phenoxyethanol and phenoxyacetic acid was reported firstly.