Prognosis and response to laser treatment of early-onset hypertrophic port-wine stains (PWS)

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• 作者：Thierry Passeron ; MD ; PhD^a ; ^b ; ^{passeron@unice.fr" class="auth_mail" title="E-mail the corresponding author} ; Aicha Salhi ; MD^c ; Jean-Michel Mazer ; MD^d ; Cé ; line Lavogiez ; MD^e ; Juliette Mazereeuw-Hautier ; MD ; PhD^f ; Chrystè ; le Galliot ; MD^g ; Anne-Marie Collet-Villette ; MD^h ; Christine Labreze ; MDⁱ ; Laurence Boon ; MD ; PhD^j ; Jean-Philippe Hardy ; MD^j ; Virginie Fayard ; MD^g ; Cristina Bulai Livideanu ; MD^f ; Gé ; rard Toubel ; MD^k ; Gabriela Georgescou ; MD^l ; Nathalie Gral ; MD^m ; Aude Maza ; MD^f ; Jean-Philippe Lacour ; MD^a
• 关键词：complications ; hypertrophic ; laser ; odontologic problems ; port-wine stains ; speech delay
• 刊名：Journal of the American Academy of Dermatology
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：75
• 期：1
• 页码：64-68
• 全文大小：681 K

文摘

There is limited information regarding early development of soft-tissue and/or bone hypertrophy with facial port-wine stains (PWS).

Objective

We sought to characterize patients with hypertrophic PWS presenting during childhood.

Methods

Patients with a facial PWS and underlying hypertrophy that developed before the age of 18 years were included in a multicenter retrospective study. Age at onset of the hypertrophy, its location, association with odontologic problems, presence of other associated complications, and response to laser treatment were recorded.

Results

A total of 98 patients were included. The mean age at onset of hypertrophy, retrieved for 77 of 98 patients, was 5.6 years. The hypertrophy was congenital in 26%. Odontologic problems were noted in 39.8% of cases. Other complications, including cataract, asymmetric development of the maxillary bone, and speech delay/disorders, were reported in 18.4%. In all, 67 patients received laser treatment. Only 3% achieved complete or nearly complete clearance of the PWS.

Limitations

As only cases of PWS with early-onset hypertrophy were included, we were unable to calculate the prevalence of this manifestation.

Conclusion

PWS with early-onset hypertrophy are associated with a high rate of complications and a poor response to laser treatment. Periodic monitoring is recommended for early detection and treatment of complications.