Structural Delineation of a Quaternary, Cleavage-Dependent Epitope at the gp41-gp120 Interface on Intact HIV-1 Env Trimers
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- 作者：Claudia Blattner1 ; 2 ; 11 ; Jeong Hyun Lee1 ; 2 ; 3 ; 11 ; Kwinten Sliepen4 ; Ronald Derking4 ; Emilia Falkowska2 ; 5 ; Alba Torrents de la Peñ ; a4 ; Albert Cupo6 ; Jean-Philippe Julien1 ; 2 ; 3 ; Marit van Gils4 ; Peter S. Lee1 ; Wenjie Peng7 ; 8 ; James C. Paulson7 ; 8 ; Pascal Poignard2 ; 5 ; Dennis R. Burton2 ; 3 ; 5 ; 9 ; John P. Moore6 ; Rogier W. Sanders4 ; 6 ; Ian A. Wilson1 ; 2 ; 3 ; 10 ; wilson@scripps.edu" class="auth_mail ; Andrew B. Ward1 ; 2 ; 3 ; abward@scripps.edu" class="auth_mail
- 刊名：Immunity
- 出版年：15 May 2014
- 年：2014
- 卷：40
- 期：5
- 页码：669-680
- 全文大小：2398 K
文摘
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PGT151 binds an interprotomer epitope formed by gp41 and gp120 on cleaved Env trimers
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The PGT151 epitope does not overlap with any other epitope described so far
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PGT151 enables isolation of functional cleaved Env from the cell membrane
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Membrane-extracted and soluble SOSIP.664 Env trimers are structurally similar