D¨¦marche clinique devant une hyperferritin¨¦mie

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• 作者：Philippe Sogni¹ ; ^{philippe.sogni@cch.aphp.fr} ; Catherine Buffet²
• 刊名：La Presse M?¡ì|dicale
• 出版年：2013
• 出版时间：April, 2013
• 年：2013
• 卷：42
• 期：4_part_P1
• 页码：405-410
• 全文大小：469 K

文摘

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Key points

A hyperferritinemia has to be interpreted in relation with age and sex.

The clinical evaluation begins with the interpretation of transferrine saturation which has to be controlled with a second fasting blood test.

In case of high transferrine saturation associated with hyperferritinemia, HFE testing has first to be realized since the first diagnosis suspected is a HFE hemochromatosis.

In case of normal transferrine saturation associated with a hyperferritinemia, the more frequent diagnosis is a metabolic syndrome, an inflammatory syndrome, a syndrome of cellular lysis or an excessive alcohol consumption.

In case of HFE hemochromatosis, phlebotomy prevents complications. The goal is to obtain and to maintain a normal-low ferritin level.

In case of metabolic syndrome, phlebotomy could be useful in case of high hepatic iron concentration measured with MRI or in case of on-alcoholic steato-hepatitis.