The amphiphilic alginate derivative (Ugi-Alg) was prepared via the Ugi four-component reaction.
The crystal structure change occurred during the synthesis of Ugi-Alg.
Ugi-Alg displays higher thermal stability in comparison with pristine alginate.
Ugi-Alg exhibits good amphiphilic functionality similar to the classic surfactant.
Ugi-Alg could form stable self-aggregated micelle in the aqueous media.