A differential gene expression study: Ptpn6 (SHP-1)-insufficiency leads to neutrophilic dermatosis-like disease (NDLD) in mice
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- 作者：Andrew B. Nesterovitcha ; Andrew_B_Nesterovitch@rush.edu" class="auth_mail" title="E-mail the corresponding author ; Zarema Arbievab ; Daniel M. Tothc ; Michael D. Tharpa ; Tibor T. Glantc
- 关键词：Ptpn6 ; tyrosine phosphatase ; non-receptor type-6 ; Hcph ; hematopoietic cell phosphatase ; Shp-1 ; Src homology 2 domain-containing tyrosine phosphatase 1 ; ITIM ; immunoreceptor tyrosine-based inhibitory motif ; ITAM ; immunoreceptor tyrosine-based activation motif ; ND ; neutrophilic dermatoses ; PG ; pyoderma gangrenosum ; SS ; Sweet&rsquo ; s syndrome ; NDLD ; neutrophilic dermatosis-like disease ; wt ; wild-type ; me ; motheaten ; meb2 ; motheaten mouse with spontaneous B2 repeat insertion in Ptpn6 gene ; RT-qPCR
- 刊名：Journal of Dermatological Science
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：83
- 期：1
- 页码：17-25
- 全文大小：2888 K
文摘
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The 63 genes in the bone marrow of NDLD mice had more than a 4-fold change with FDR <0.0001 presenting a unique NDLD gene expression signature.
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C-type lectin innate immunity receptors were significantly up-regulated in both NDLD bone marrow and skin.
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The IL1b (but not IL1a) gene was also significantly overexpressed in skin samples.
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The footprint of meb2 mutation in Ptpn6 overlaps with other genetic modifications (IL1b-Tg, Ikkb-Tg) with similar phenotypes.