CaMKII and at least two unidentified kinases phosphorylate regulatory light chain in non-contracting cardiomyocytes
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- 作者：Hilde Eikemoa ; b ; 1 ; hilde.eikemo@ntnu.no" class="auth_mail" title="E-mail the corresponding author ; Lise Romá ; n Moltzaua ; b ; 1 ; l.r.moltzau@medisin.uio.no" class="auth_mail" title="E-mail the corresponding author ; Cam H.T. Nguyena ; b ; Finn Olav Levya ; b ; f.o.levy@medisin.uio.no" class="auth_mail" title="E-mail the corresponding author ; Tor Skomedala ; b ; tor.skomedal@medisin.uio.no" class="auth_mail" title="E-mail the corresponding author ; Jan-Bjø ; rn Osnesa ; b ; j.b.osnes@medisin.uio.no" class="auth_mail" title="E-mail the corresponding author
- 关键词：Regulatory light chain (RLC ; myosin light chain 2) ; Phosphorylation ; Myosin light chain kinase ; Myosin light chain phosphatase ; Ca2+/calmodulin-dependent kinase II
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：12 August 2016
- 年：2016
- 卷：477
- 期：1
- 页码：14-19
- 全文大小：765 K
文摘
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Regulatory light chain (RLC) phosphorylation in non-contracting cardiomyocytes involves CaMKII.
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Myosin light chain kinase is not involved in RLC phosphorylation in non-contracting cardiomyocytes.
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At least two other kinase activities contribute, one Ca2+/calmodulin-dependent and one Ca2+/calmodulin-independent.