Permeability barriers for generating a unique ciliary protein and lipid composition
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- 作者：Kristen J Verhey1 ; kjverhey@umich.edu" class="auth_mail" title="E-mail the corresponding author ; Weidong Yang2
- 刊名：Current Opinion in Cell Biology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：41
- 期：Complete
- 页码：109-116
- 全文大小：1005 K
文摘
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Nucleoporins comprise a permeability barrier for the entry of soluble proteins.
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MKS proteins regulate the entry of membrane proteins at the transition zone.
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NPHP proteins are structural components of the transition zone and regulate protein entry.
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The inositol 5-phosphatase INPP5E creates a PI(4)P environment in the cilium.
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Extraciliary PI(4,5)P2 may regulate exocytosis and endocytosis adjacent to the cilium.