tPA promotes cortical neuron survival via mTOR-dependent mechanisms
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- 作者：Julia A. Grummisch Julia.Grummisch@carleton.ca" class="auth_mail" title="E-mail the corresponding author ; Nafisa M. Jadavji Nafisa.Jadavji@carleton.ca" class="auth_mail" title="E-mail the corresponding author ; Patrice D. Smith ; Patrice.Smith@carleton.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：DIV ; days in vitro ; JAK ; Janus kinase ; mTOR ; mammalian target of rapamycin ; p2 ; postnatal day 2 ; PDL ; poly-d-lysine ; p-S6 ; phospho-S6 ; p-STAT3 ; phosphorylated signal transducer and activator of transcription 3 ; tPA ; tissue plasminogen activator
- 刊名：Molecular and Cellular Neuroscience
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：74
- 期：Complete
- 页码：25-33
- 全文大小：772 K
文摘
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The thrombolytic agent, tPA has a significant beneficial impact on postnatal cortical neuron viability in vitro
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Neuroprotective effect of tPA treatment on postnatal primary cortical neurons in vitro
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tPA-mediated cell survival requires mTOR and JAK/STAT pathway activation
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Increase in p-S6 expression following tPA treatment in postnatal cortical neurons