PLD1 regulates Xenopus convergent extension movements by mediating Frizzled7 endocytosis for Wnt/PCP signal activation
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- 作者：Hyeyoon Leea ; 1 ; Seung Joon Leea ; 1 ; 2 ; Gun-Hwa Kimb ; c ; Inchul Yeoa ; Jin-Kwan Hana ; jkh@postech.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Phospholipase D ; Wnt/PCP signaling ; Xenopus laevis ; Gastrulation ; Convergent extension movements ; Frizzled7 ; Endocytosis
- 刊名：Developmental Biology
- 出版年：2016
- 出版时间：1 March 2016
- 年：2016
- 卷：411
- 期：1
- 页码：38-49
- 全文大小：8484 K
文摘
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Xenopus PLD1 is required for the CE movements during gastrulation.
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Xenopus PLD1 activates Wnt/PCP signaling pathway.
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Xenopus PLD1 regulates Fz7 receptor endocytosis.
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Dynamin is functionally associated with PLD1 for Fz7 endocytosis in CE movements.