Early LPS-induced ERK activation in retinal pigment epithelium cells is dependent on PIP₂-PLC

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• 作者：Melina V. Mateos ; ^{mvmateos@criba.edu.ar" class="auth_mail" title="E-mail the corresponding author} ; Constanza B. Kamerbeek ; Norma M. Giusto ; Gabriela A. Salvador
• 关键词：ERK ; extracellular signal-regulated kinase ; HRP ; horseradish peroxidase ; LPS ; lipopolysaccharide ; PIP2-PLC ; phosphatidylinositol bisphosphate-phospholipase C ; PLD ; phospholipase D ; RPE ; retinal pigment epithelium
• 刊名：Data in Brief
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：7
• 期：Complete
• 页码：423-427
• 全文大小：369 K

文摘

This article presents additional data regarding the study “The phospholipase D pathway mediates the inflammatory response of the retinal pigment epithelium” [1]. The new data presented here show that short exposure of RPE cells to lipopolysaccharide (LPS) induces an early and transient activation of the extracellular signal-regulated kinase (ERK1/2). This early ERK1/2 activation is dependent on phosphatidylinositol bisphosphate-phospholipase C (PIP₂-PLC). On the contrary, neither the phospholipase D 1 (PLD1) nor the PLD2 inhibition is able to modulate the early ERK1/2 activation induced by LPS in RPE cells.