Phospholipase D enzymes facilitate IL-17- and TNFα-induced expression of proinflammatory genes in rheumatoid arthritis synovial fibroblasts (RASF)
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- 作者：Sean C. Friday1 ; fridays@umich.edu" class="auth_mail" title="E-mail the corresponding author ; David A. Fox ; dfox@med.umich.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：IL-17 ; TNF alpha ; Rheumatoid arthritis ; PLD ; Fibroblast-like synoviocytes ; CAY10593
- 刊名：Immunology Letters
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：174
- 期：Complete
- 页码：9-18
- 全文大小：2181 K
文摘
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Synovial fibroblasts express two types of phospholipase D, PLD1 and PLD2.
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PLD regulates production of pro-inflammatory cytokines by synovial fibroblasts.
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In synovial organ cultures PLD inhibitors inhibit release of interleukins 6 and 8.
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The effects of PLD are primarily post-transcriptional.
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PLD inhibitors could be evaluated for clinical effects on inflammatory arthritis.