Comparative study on prediction performance of photosafety testing tools on photoallergens
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- 作者：Satomi Onouea ; onoue@u-shizuoka-ken.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Hiroto Ohtakea ; Gen Suzukia ; Yoshiki Setoa ; Hayato Nishidab ; Morihiko Hirotab ; Takao Ashikagab ; Hirokazu Kouzukib
- 关键词：3T3 NRU PT ; 3T3 neutral red uptake phototoxicity testing ; AOP ; Adverse Outcome Pathway ; DMSO ; dimethyl sulfoxide ; ICH ; International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use ; IFRA ; International Fragrance Association ; JaCVAM ; Japanese Center for the Validation of Alternative Methods ; JPMA ; Japan Pharmaceutical Manufacturers Association ; MEC ; molar extinction coefficient ; mROS assay ; micellar ROS assay ; NaPB ; sodium phosphate buffer
- 刊名：Toxicology in Vitro
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：33
- 期：Complete
- 页码：147-152
- 全文大小：435 K
文摘
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Three in vitro photosafety screening systems were conducted for 30 chemicals to predict photoallergenic potential.
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They were found to be partly applicable to photoallergic prediction.
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Reliable photoallergic prediction might be challenging for the 3T3 NRU PT.
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The in vitro photochemical assays could provide photoallergenic information with some false-positives.