Purine analogs as phosphatidylinositol 4-kinase IIIβ inhibitors

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• 作者：Michal &Scaron ; á ; la^a ; Martin Kö ; gler^a ; Pavla Plačková ; ^a ; Ivana Mejdrová ; ^a ; ^b ; Hubert Hřebabecký ; ^a ; Eli&scaron ; ka Prochá ; zková ; ^a ; Dmytro Strunin^a ; Gary Lee^c ; Gabriel Birkus^c ; Jan Weber^a ; Helena Mertlí ; ková ; -Kaiserová ; ^a ; Radim Nencka^a ;
• 关键词：Phosphatidylinositol 4-kinase ; Purine ; PI4K IIIβ ; Antiviral agent ; Hepatitis C virus
• 刊名：Bioorganic & Medicinal Chemistry Letters
• 出版年：2016
• 出版时间：1 June 2016
• 年：2016
• 卷：26
• 期：11
• 页码：2706-2712
• 全文大小：2262 K

文摘

We report on an extensive structure–activity relationship study of novel PI4K IIIβ inhibitors. The purine derivative of the potent screening hit T-00127-HEV1 has served as a suitable starting point for a thorough investigation of positions 8 and 2. While position 8 of the purine scaffold can only bear a small substituent to maintain the inhibitory activity, position 2 is opened for extensive modification and can accommodate even substituted phenyl rings without the loss of PI4K IIIβ inhibitory activity. These empirical observations nicely correlate with the results of our docking study, which suggests that position 2 directs towards solution and can provide the necessary space for the interaction with remote residues of the enzyme, whereas the cavity around position 8 is strictly limited. The obtained compounds have also been subjected to antiviral screening against a panel of (+)ssRNA viruses.