Development of a patient-reported outcome instrument to assess complex activities of daily living and interpersonal functioning in persons with mild cognitive impairment: The qualitative research phase

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• 作者：Mark Forrest Gordon^a ; ^{mark.gordon@boehringer-ingelheim.com" class="auth_mail" title="E-mail the corresponding author} ; William R. Lenderking^b ; Amy Duhig^c ; Julie Chandler^d ; J. Jason Lundy^e ; David S. Miller^f ; Elisabeth Piault-Louis^g ; Rachelle S. Doody^h ; Douglas Galaskoⁱ ; Serge Gauthier^j ; Lori Frank^k ; on behalf of the Patient-Reported Outcome Consortium's Cognition Working Group
• 关键词：Cognition ; Mild cognitive impairment ; Alzheimer's disease ; Patient-reported outcome ; Activities of daily living ; Interpersonal functioning ; Qualitative ; Critical Path Institute
• 刊名：Alzheimer's & Dementia
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：12
• 期：1
• 页码：75-84
• 全文大小：666 K

文摘

As drug development research efforts move toward studying patients earlier in the course of Alzheimer's disease (AD), it is important to incorporate the patient's perspective into measurement of outcomes.

Methods

This article summarizes the qualitative work of the Patient-Reported Outcome Consortium's Cognition Working Group in the development of a new self-reported outcome measure in persons with mild cognitive impairment (MCI) due to suspected AD, herein referred to as MCI.

Results

The draft measure captures the patient's voice for two functional domains, complex activities of daily living and interpersonal functioning.

Discussion

This work represents a series of initial steps in the development of this rating scale. The next steps are to conduct psychometric analysis and evaluate the role of insight.