Bioresorbable glass effect on the physico-chemical properties of bilayered scaffolds for osteochondral regeneration

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• 作者：Piergiorgio Gentile ; Valeria Chiono ; Chiara Tonda-Turo ; Clara Mattu ; Francesco Baino ; Chiara Vitale-Brovarone ; Gianluca Ciardelli
• 关键词：Composite scaffolds ; Bilayered ; Bioresorbable glass ; Gelatin ; Osteochondral bone
• 刊名：Materials Letters
• 出版年：2012
• 出版时间：15 December, 2012
• 年：2012
• 卷：89
• 期：Complete
• 页码：74-76
• 全文大小：345 K

文摘

In this work, bilayered and bioresorbable composite scaffolds are developed with mechanical and functional properties for osteochondral tissue engineering. Porous scaffolds made of gelatin (G) and bioresorbable phosphate glass (I-CEL2) with different compositions (I-CEL2/G 0/100; 30/70; 70/30  % w/w) were fabricated by freeze-drying. Samples were crosslinked using ¦Ã-glycidoxypropyltrimethoxysilane to improve mechanical strength and thermal stability. I-CEL2/G samples showed interconnected pores having an average diameter ranging from 139¡À5 ¦Ìm for I-CEL2/G 0/100 to 116¡À9 ¦Ìm for I-CEL2/G 70/30. GPTMS-crosslinking and the increase of I-CEL2 amount stabilized the composites to water solution, as shown by swelling tests. The compressive modulus increased by increasing I-CEL2 amount up to 7.6¡À0.5 MPa for I-CEL2/G 70/30.